Detalhe da pesquisa
1.
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.
Cell
; 182(4): 1009-1026.e29, 2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32730809
2.
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.
Cell
; 171(3): 696-709.e23, 2017 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28965760
3.
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.
Nature
; 571(7765): 398-402, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31292548
4.
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth.
Nat Chem Biol
; 17(8): 856-864, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33927411
5.
Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.
Blood
; 135(20): 1772-1782, 2020 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32219446
6.
Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation.
Bioorg Med Chem Lett
; 53: 128414, 2021 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34666187
7.
Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4-MyD88 Complex.
J Immunol
; 202(9): 2737-2746, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30885957
8.
Chemical proteomic identification of functional cysteines with atypical electrophile reactivities.
Tetrahedron Lett
; 672021 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33776155
9.
2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles.
J Am Chem Soc
; 142(19): 8972-8979, 2020 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32302104
10.
A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex.
Angew Chem Int Ed Engl
; 59(10): 3896-3899, 2020 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31863675
11.
The Proteome-Wide Potential for Reversible Covalency at Cysteine.
Angew Chem Int Ed Engl
; 58(33): 11385-11389, 2019 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31222866
12.
Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes.
J Am Chem Soc
; 140(26): 8069-8073, 2018 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29894184
13.
Covalent inhibitors of nicotinamide N-methyltransferase (NNMT) provide evidence for target engagement challenges in situ.
Bioorg Med Chem Lett
; 28(16): 2682-2687, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29731364
14.
Chemical Proteomic Profiling of Human Methyltransferases.
J Am Chem Soc
; 138(40): 13335-13343, 2016 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27689866
15.
GeneDig: a web application for accessing genomic and bioinformatics knowledge.
BMC Bioinformatics
; 16: 67, 2015 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25888373
16.
Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets.
ACS Cent Sci
; 7(9): 1524-1534, 2021 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34584954
17.
Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator.
Cell Rep
; 31(12): 107805, 2020 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32579931
18.
Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling.
ACS Med Chem Lett
; 9(6): 563-568, 2018 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29937983